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SEC EDGAR · Forms 3/4/5Updated through Oct 30, 2026•43 filings

SYRE

Spyre Therapeutics, Inc.

Net sales of $15.3M over the last 3 months

4 sellers account for the net balance. There is no cluster of three distinct buyers within 30 days. We found no CEO/CFO purchases over 12 months.

How to read this signal

Only open-market P purchases and S sales count toward the signal. Vesting, options, taxes and gifts remain in the source data but do not trigger alerts. Rule 10b5-1 trades are shown as informational.

JSON example

3-month balance

−$15,274,234

0 buyers · 4 sellers

12-month purchases

$0.00

0 distinct insiders

12-month sales

$441,353,651

10 distinct insiders

Highlighted alerts

3

92 Rule 10b5-1 trades treated as informational

Buying cluster · 30 days

Fewer than three distinct buyers

CEO/CFO purchases · 12 months

No executive purchases found

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Form 4 raw → Raspberry

The value is in what we do not call a signal.

The SEC XML stores every transaction. Raspberry keeps that evidence, reads the footnotes and separates voluntary open-market activity from vesting, option exercises, gifts, tax withholding, stock purchase and dividend reinvestment plans and pre-programmed 10b5-1 trades.

100
Raw transactions
Everything returned by the filing
95
Voluntary view
P/S trades after deterministic checks
33
Administrative noise
Stored, never alerted
87
10b5-1
Shown as informational
SEC ownership XML facts
Code
S
Shares
18,232
Price
$89.35
Footnotes
8

This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $85.60 to $86.53, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $86.60 to $87.57, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $87.64 to $88.59, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $88.69 to $89.38, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range. The transaction reported reflects the sale of shares of the Issuer's common stock in satisfaction of the Reporting Person's tax liability in connection with the settlement of 33,738 restricted stock units ("RSUs"). This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade made by the Reporting Person. Includes 33,738 RSUs. Each RSU represents a contingent right to receive, upon vesting, one share of the Issuer's common stock. The RSUs vest on September 1, 2027, subject to the Reporting Person's continued employment with the Issuer. This option represents a right to purchase 404,857 shares of the Issuer's common stock (which have been adjusted to reflect the Issuer's 1-for-25 reverse stock split on September 8, 2023), one quarter of which vested and became exercisable on September 1, 2024, with the remaining three quarters vesting in monthly installments over the following three years, subject to the Reporting Person's continued employment with the Issuer.

Raspberry interpretation
Informational — no alert

Reason: tax_withholding. The filing footnotes identify tax withholding. The trade is reported under a Rule 10b5-1 plan.

Verify in SEC EDGAR

Recent transactions

Voluntary purchases and sales; administrative noise stays hidden.

95 transactions

King-Jones Heidy

See Remarks

Sale 10b5-1
Shares
2,600
Price
$93.46
Value
$242,996
Open SEC filing

King-Jones Heidy

See Remarks

Sale 10b5-1
Shares
2,100
Price
$92.70
Value
$194,670
Open SEC filing

King-Jones Heidy

See Remarks

Sale 10b5-1
Shares
7,228
Price
$91.35
Value
$660,278
Open SEC filing

King-Jones Heidy

See Remarks

Sale 10b5-1
Shares
16,605
Price
$90.35
Value
$1,500,262
Open SEC filing

King-Jones Heidy

See Remarks

Sale 10b5-1
Shares
400
Price
$89.24
Value
$35,696
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
100
Price
$93.91
Value
$9,391
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
4,990
Price
$93.37
Value
$465,916
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
3,989
Price
$92.31
Value
$368,225
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
2,638
Price
$91.49
Value
$241,351
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
2,683
Price
$90.10
Value
$241,738
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
600
Price
$89.14
Value
$53,484
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
229
Price
$93.57
Value
$21,428
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
3,071
Price
$92.95
Value
$285,449
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
2,100
Price
$91.92
Value
$193,032
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
1,500
Price
$90.27
Value
$135,405
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
600
Price
$89.07
Value
$53,442
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
17,500
Price
$89.89
Value
$1,573,075
Open SEC filing

King-Jones Heidy

See Remarks

Sale 10b5-1
Shares
400
Price
$90.00
Value
$36,000
Open SEC filing

King-Jones Heidy

See Remarks

Sale 10b5-1
Shares
400
Price
$89.38
Value
$35,752
Open SEC filing

King-Jones Heidy

See Remarks

Sale 10b5-1
Shares
6,206
Price
$88.17
Value
$547,183
Open SEC filing

King-Jones Heidy

See Remarks

Sale 10b5-1
Shares
16,548
Price
$87.20
Value
$1,442,986
Open SEC filing

King-Jones Heidy

See Remarks

Sale 10b5-1
Shares
4,845
Price
$86.40
Value
$418,608
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
200
Price
$89.04
Value
$17,808
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
2,016
Price
$88.03
Value
$177,468
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
4,384
Price
$87.11
Value
$381,890
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
900
Price
$86.25
Value
$77,625
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
400
Price
$89.07
Value
$35,628
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
3,700
Price
$88.06
Value
$325,822
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
8,400
Price
$87.15
Value
$732,060
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
2,500
Price
$86.36
Value
$215,900
Open SEC filing

Albers Jeffrey W.

Director

Sale 10b5-1
Shares
10,000
Price
$104.68
Value
$1,046,800
Open SEC filing

Albers Jeffrey W.

Director

Sale 10b5-1
Shares
8,000
Price
$104.38
Value
$835,040
Open SEC filing

Albers Jeffrey W.

Director

Sale 10b5-1
Shares
5,000
Price
$104.47
Value
$522,350
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
100
Price
$97.10
Value
$9,710
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
2,300
Price
$96.30
Value
$221,490
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
5,100
Price
$95.21
Value
$485,571
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
16
Price
$97.46
Value
$1,559
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
1,392
Price
$96.82
Value
$134,773
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
5,635
Price
$95.93
Value
$540,566
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
7,157
Price
$95.10
Value
$680,631
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
800
Price
$93.97
Value
$75,176
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
1,725
Price
$88.37
Value
$152,438
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
5,775
Price
$87.55
Value
$505,601
Open SEC filing

Sloan Sheldon

Chief Medical Officer

Sale 10b5-1
Shares
1,834
Price
$88.34
Value
$162,016
Open SEC filing

Sloan Sheldon

Chief Medical Officer

Sale 10b5-1
Shares
6,500
Price
$87.52
Value
$568,880
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
590
Price
$88.91
Value
$52,457
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
4,234
Price
$88.12
Value
$373,100
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
10,176
Price
$87.44
Value
$889,789
Open SEC filing

Burrows Scott L

Chief Financial Officer

SaleAlert
Shares
10,000
Price
$87.14
Value
$871,400
Open SEC filing

Burrows Scott L

Chief Financial Officer

SaleAlert
Shares
5,000
Price
$87.12
Value
$435,600
Open SEC filing

Fairmount Funds Management LLC

Director

SaleAlert
Shares
4,684,781
Price
$85.31
Value
$399,658,667
Open SEC filing

HENDERSON MICHAEL THOMAS

Director

Sale 10b5-1
Shares
20,000
Price
$100.00
Value
$2,000,000
Open SEC filing

Sloan Sheldon

Chief Medical Officer

Sale 10b5-1
Shares
8,333
Price
$75.00
Value
$624,975
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
3,294
Price
$71.38
Value
$235,126
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
8,149
Price
$70.50
Value
$574,505
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
3,557
Price
$69.40
Value
$246,856
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
3,100
Price
$72.06
Value
$223,386
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
2,599
Price
$70.77
Value
$183,931
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
1,801
Price
$69.75
Value
$125,620
Open SEC filing

HENDERSON MICHAEL THOMAS

Director

Sale 10b5-1
Shares
19,269
Price
$75.35
Value
$1,451,919
Open SEC filing

HENDERSON MICHAEL THOMAS

Director

Sale 10b5-1
Shares
24,814
Price
$74.76
Value
$1,855,095
Open SEC filing

HENDERSON MICHAEL THOMAS

Director

Sale 10b5-1
Shares
33,513
Price
$73.72
Value
$2,470,578
Open SEC filing

HENDERSON MICHAEL THOMAS

Director

Sale 10b5-1
Shares
2,404
Price
$72.57
Value
$174,458
Open SEC filing

Sloan Sheldon

Chief Medical Officer

Sale 10b5-1
Shares
400
Price
$75.37
Value
$30,148
Open SEC filing

Sloan Sheldon

Chief Medical Officer

Sale 10b5-1
Shares
5,059
Price
$74.60
Value
$377,401
Open SEC filing

Sloan Sheldon

Chief Medical Officer

Sale 10b5-1
Shares
10,358
Price
$73.74
Value
$763,799
Open SEC filing

Sloan Sheldon

Chief Medical Officer

Sale 10b5-1
Shares
12,777
Price
$72.94
Value
$931,954
Open SEC filing

Sloan Sheldon

Chief Medical Officer

Sale 10b5-1
Shares
8,777
Price
$71.56
Value
$628,082
Open SEC filing

Sloan Sheldon

Chief Medical Officer

Sale 10b5-1
Shares
19,656
Price
$70.61
Value
$1,387,910
Open SEC filing

Sloan Sheldon

Chief Medical Officer

Sale 10b5-1
Shares
21,306
Price
$69.53
Value
$1,481,406
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
12,500
Price
$71.37
Value
$892,125
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
300
Price
$74.96
Value
$22,488
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
1,700
Price
$74.23
Value
$126,191
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
3,100
Price
$73.14
Value
$226,734
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
1,000
Price
$71.76
Value
$71,760
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
3,600
Price
$70.77
Value
$254,772
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
5,300
Price
$69.54
Value
$368,562
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
1,300
Price
$49.98
Value
$64,974
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
6,200
Price
$49.21
Value
$305,102
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
2,656
Price
$49.92
Value
$132,588
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
12,344
Price
$49.20
Value
$607,325
Open SEC filing

Sloan Sheldon

Chief Medical Officer

Sale 10b5-1
Shares
7,958
Price
$50.00
Value
$397,900
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
200
Price
$41.66
Value
$8,332
Open SEC filing

Burrows Scott L

Chief Financial Officer

Sale 10b5-1
Shares
2,300
Price
$40.56
Value
$93,288
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
9,100
Price
$42.49
Value
$386,659
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
5,900
Price
$41.73
Value
$246,207
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
14,043
Price
$32.87
Value
$461,593
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
957
Price
$31.82
Value
$30,452
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
100
Price
$32.39
Value
$3,239
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
2,191
Price
$31.79
Value
$69,652
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
12,709
Price
$30.47
Value
$387,243
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
4,005
Price
$29.83
Value
$119,469
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
10,995
Price
$28.73
Value
$315,886
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
16,845
Price
$23.66
Value
$398,553
Open SEC filing

Turtle Cameron

Chief Executive Officer

Sale 10b5-1
Shares
28,155
Price
$23.13
Value
$651,225
Open SEC filing

“Alert” means a voluntary, unscheduled transaction according to the filing; it is not an investment recommendation. Official source: SEC EDGAR.