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SEC EDGAR · Forms 3/4/5Updated through Oct 30, 2026•155 filings

IONS

IONIS PHARMACEUTICALS INC

Net purchases of $1.1M over the last 3 months

1 buyer account for the net balance. There is no cluster of three distinct buyers within 30 days. We found no CEO/CFO purchases over 12 months.

How to read this signal

Only open-market P purchases and S sales count toward the signal. Vesting, options, taxes and gifts remain in the source data but do not trigger alerts. Rule 10b5-1 trades are shown as informational.

JSON example

3-month balance

+$1,058,700

1 buyers · 0 sellers

12-month purchases

$1,058,700

1 distinct insiders

12-month sales

$123,860,130

19 distinct insiders

Highlighted alerts

12

88 Rule 10b5-1 trades treated as informational

Buying cluster · 30 days

Fewer than three distinct buyers

CEO/CFO purchases · 12 months

No executive purchases found

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Form 4 raw → Raspberry

The value is in what we do not call a signal.

The SEC XML stores every transaction. Raspberry keeps that evidence, reads the footnotes and separates voluntary open-market activity from vesting, option exercises, gifts, tax withholding, stock purchase and dividend reinvestment plans and pre-programmed 10b5-1 trades.

100
Raw transactions
Everything returned by the filing
100
Voluntary view
P/S trades after deterministic checks
71
Administrative noise
Stored, never alerted
68
10b5-1
Shown as informational
SEC ownership XML facts
Code
S
Shares
1,357
Price
$43.54
Footnotes
5

Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award. The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $43.1383 to $43.538918 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4. Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value. Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Raspberry interpretation
Informational — no alert

Reason: tax_withholding. The filing footnotes identify tax withholding.

Verify in SEC EDGAR

Recent transactions

Voluntary purchases and sales; administrative noise stays hidden.

100 transactions

Hayden Michael R

Director

PurchaseAlert
Shares
5,000
Price
$51.60
Value
$258,000
Open SEC filing

Hayden Michael R

Director

PurchaseAlert
Shares
15,000
Price
$53.38
Value
$800,700
Open SEC filing

BENNETT C FRANK

EVP, Chief Scientific Officer

Sale 10b5-1
Shares
15,000
Price
$85.46
Value
$1,281,930
Open SEC filing

BENNETT C FRANK

EVP, Chief Scientific Officer

Sale 10b5-1
Shares
5,536
Price
$83.58
Value
$462,693
Open SEC filing

Diaz Allene M.

Director

Sale 10b5-1
Shares
10,111
Price
$85.42
Value
$863,637
Open SEC filing

Kordasiewicz Holly B.

EVP, Chief Development Officer

Sale 10b5-1
Shares
362
Price
$84.30
Value
$30,517
Open SEC filing

KLEIN JOSEPH III

Director

Sale 10b5-1
Shares
11,419
Price
$79.04
Value
$902,551
Open SEC filing

KLEIN JOSEPH III

Director

Sale 10b5-1
Shares
99
Price
$79.45
Value
$7,866
Open SEC filing

Baroldi Joseph

EVP, Chief Business Officer

Sale 10b5-1
Shares
5,635
Price
$80.16
Value
$451,699
Open SEC filing

O'NEIL PATRICK R.

EVP CLO & General Counsel

Sale 10b5-1
Shares
3,069
Price
$80.00
Value
$245,520
Open SEC filing

Schneider Eugene

EVP, Chf Clinical Develop Ofcr

Sale 10b5-1
Shares
26,000
Price
$81.05
Value
$2,107,196
Open SEC filing

Monia Brett P

Chief Executive Officer

Sale 10b5-1
Shares
50,000
Price
$80.59
Value
$4,029,500
Open SEC filing

Monia Brett P

Chief Executive Officer

Sale 10b5-1
Shares
21,072
Price
$78.49
Value
$1,653,941
Open SEC filing

Swayze Eric

EVP Research

Sale 10b5-1
Shares
10,602
Price
$79.18
Value
$839,492
Open SEC filing

Monia Brett P

Chief Executive Officer

Sale 10b5-1
Shares
14,565
Price
$78.41
Value
$1,142,082
Open SEC filing

BERTHELSEN SPENCER R

Director

Sale 10b5-1
Shares
8,000
Price
$73.49
Value
$587,920
Open SEC filing

Kordasiewicz Holly B.

EVP, Chief Development Officer

Sale 10b5-1
Shares
19,842
Price
$74.05
Value
$1,469,306
Open SEC filing

Kordasiewicz Holly B.

EVP, Chief Development Officer

Sale 10b5-1
Shares
41,004
Price
$73.09
Value
$2,997,122
Open SEC filing

BERTHELSEN SPENCER R

Director

Sale 10b5-1
Shares
8,000
Price
$75.67
Value
$605,360
Open SEC filing

Monia Brett P

Chief Executive Officer

Sale 10b5-1
Shares
3,220
Price
$78.68
Value
$253,347
Open SEC filing

Monia Brett P

Chief Executive Officer

Sale 10b5-1
Shares
1,316
Price
$78.01
Value
$102,665
Open SEC filing

LOSCALZO JOSEPH

Director

Sale 10b5-1
Shares
17,781
Price
$75.58
Value
$1,343,934
Open SEC filing

LOSCALZO JOSEPH

Director

Sale 10b5-1
Shares
59,508
Price
$74.90
Value
$4,457,292
Open SEC filing

KLEIN JOSEPH III

Director

Sale 10b5-1
Shares
1,431
Price
$74.45
Value
$106,534
Open SEC filing

KLEIN JOSEPH III

Director

Sale 10b5-1
Shares
8,680
Price
$73.35
Value
$636,704
Open SEC filing

Baroldi Joseph

EVP, Chief Business Officer

Sale 10b5-1
Shares
1,626
Price
$71.79
Value
$116,727
Open SEC filing

PARSHALL B LYNNE

Director

Sale 10b5-1
Shares
534
Price
$76.97
Value
$41,102
Open SEC filing

PARSHALL B LYNNE

Director

Sale 10b5-1
Shares
4,466
Price
$76.19
Value
$340,265
Open SEC filing

Devers Shannon L.

EVP, Chief Human Resources Ofc

Sale 10b5-1
Shares
6,193
Price
$74.05
Value
$458,613
Open SEC filing

KLEIN JOSEPH III

Director

Sale 10b5-1
Shares
2,216
Price
$75.95
Value
$168,314
Open SEC filing

KLEIN JOSEPH III

Director

Sale 10b5-1
Shares
20,105
Price
$75.50
Value
$1,517,988
Open SEC filing

Schneider Eugene

EVP, Chf Clinical Develop Ofcr

Sale 10b5-1
Shares
5,812
Price
$70.97
Value
$412,486
Open SEC filing

HOUGEN ELIZABETH L

EVP, Finance & CFO

Sale 10b5-1
Shares
10,172
Price
$73.21
Value
$744,662
Open SEC filing

HOUGEN ELIZABETH L

EVP, Finance & CFO

Sale 10b5-1
Shares
9,440
Price
$72.77
Value
$686,902
Open SEC filing

HOUGEN ELIZABETH L

EVP, Finance & CFO

Sale 10b5-1
Shares
205,608
Price
$72.38
Value
$14,882,113
Open SEC filing

Monia Brett P

Chief Executive Officer

Sale 10b5-1
Shares
17,591
Price
$76.34
Value
$1,342,909
Open SEC filing

Monia Brett P

Chief Executive Officer

Sale 10b5-1
Shares
16,512
Price
$75.47
Value
$1,246,235
Open SEC filing

Jenne Kyle

EVP, Chf GL Pdt Str Ofcr

Sale 10b5-1
Shares
16,086
Price
$76.30
Value
$1,227,362
Open SEC filing

Jenne Kyle

EVP, Chf GL Pdt Str Ofcr

Sale 10b5-1
Shares
21,191
Price
$75.50
Value
$1,599,963
Open SEC filing

O'NEIL PATRICK R.

EVP CLO & General Counsel

Sale 10b5-1
Shares
10,148
Price
$75.25
Value
$763,662
Open SEC filing

Monia Brett P

Chief Executive Officer

Sale 10b5-1
Shares
1,684
Price
$75.58
Value
$127,282
Open SEC filing

Monia Brett P

Chief Executive Officer

Sale 10b5-1
Shares
117,604
Price
$75.26
Value
$8,850,642
Open SEC filing

Monia Brett P

Chief Executive Officer

Sale 10b5-1
Shares
7,382
Price
$74.11
Value
$547,087
Open SEC filing

LOSCALZO JOSEPH

Director

Sale 10b5-1
Shares
200
Price
$80.00
Value
$16,000
Open SEC filing

Baroldi Joseph

EVP, Chief Business Officer

Sale 10b5-1
Shares
201
Price
$80.00
Value
$16,080
Open SEC filing

Baroldi Joseph

EVP, Chief Business Officer

Sale 10b5-1
Shares
238
Price
$80.00
Value
$19,040
Open SEC filing

LOSCALZO JOSEPH

Director

Sale 10b5-1
Shares
832
Price
$80.33
Value
$66,833
Open SEC filing

KLEIN JOSEPH III

Director

Sale 10b5-1
Shares
1,012
Price
$80.82
Value
$81,788
Open SEC filing

KLEIN JOSEPH III

Director

Sale 10b5-1
Shares
6,794
Price
$80.00
Value
$543,486
Open SEC filing

KLEIN JOSEPH III

Director

Sale 10b5-1
Shares
13,526
Price
$79.17
Value
$1,070,908
Open SEC filing

Diaz Allene M.

Director

Sale 10b5-1
Shares
1,005
Price
$80.80
Value
$81,203
Open SEC filing

Diaz Allene M.

Director

Sale 10b5-1
Shares
14,608
Price
$79.88
Value
$1,166,814
Open SEC filing

Diaz Allene M.

Director

Sale 10b5-1
Shares
39,265
Price
$79.11
Value
$3,106,411
Open SEC filing

Devers Shannon L.

EVP, Chief Human Resources Ofc

Sale 10b5-1
Shares
755
Price
$80.84
Value
$61,032
Open SEC filing

Devers Shannon L.

EVP, Chief Human Resources Ofc

Sale 10b5-1
Shares
5,030
Price
$80.00
Value
$402,395
Open SEC filing

Devers Shannon L.

EVP, Chief Human Resources Ofc

Sale 10b5-1
Shares
14,321
Price
$79.12
Value
$1,133,006
Open SEC filing

BENNETT C FRANK

EVP, Chief Scientific Officer

Sale 10b5-1
Shares
802
Price
$80.76
Value
$64,771
Open SEC filing

BENNETT C FRANK

EVP, Chief Scientific Officer

Sale 10b5-1
Shares
12,687
Price
$79.88
Value
$1,013,410
Open SEC filing

BENNETT C FRANK

EVP, Chief Scientific Officer

Sale 10b5-1
Shares
71,600
Price
$79.10
Value
$5,663,488
Open SEC filing

Baroldi Joseph

EVP, Chief Business Officer

Sale 10b5-1
Shares
36
Price
$81.01
Value
$2,916
Open SEC filing

Baroldi Joseph

EVP, Chief Business Officer

Sale 10b5-1
Shares
2,088
Price
$80.41
Value
$167,892
Open SEC filing

Baroldi Joseph

EVP, Chief Business Officer

Sale 10b5-1
Shares
4,096
Price
$79.36
Value
$325,059
Open SEC filing

Swayze Eric

EVP Research

Sale 10b5-1
Shares
6,207
Price
$82.07
Value
$509,403
Open SEC filing

Swayze Eric

EVP Research

Sale 10b5-1
Shares
9,435
Price
$81.56
Value
$769,511
Open SEC filing

PARSHALL B LYNNE

Director

Sale 10b5-1
Shares
5,000
Price
$82.72
Value
$413,589
Open SEC filing

Monia Brett P

Chief Executive Officer

Sale 10b5-1
Shares
29,430
Price
$85.79
Value
$2,524,820
Open SEC filing

BENNETT C FRANK

EVP, Chief Scientific Officer

Sale 10b5-1
Shares
16,463
Price
$83.03
Value
$1,366,897
Open SEC filing

BENNETT C FRANK

EVP, Chief Scientific Officer

Sale 10b5-1
Shares
48,626
Price
$83.03
Value
$4,037,339
Open SEC filing

BENNETT C FRANK

EVP, Chief Scientific Officer

Sale 10b5-1
Shares
20,000
Price
$82.60
Value
$1,651,980
Open SEC filing

Swayze Eric

EVP Research

SaleAlert
Shares
6,179
Price
$82.93
Value
$512,446
Open SEC filing

Schneider Eugene

EVP, Chf Clinical Develop Ofcr

SaleAlert
Shares
6,179
Price
$83.45
Value
$515,630
Open SEC filing

O'NEIL PATRICK R.

EVP CLO & General Counsel

SaleAlert
Shares
6,179
Price
$83.53
Value
$516,154
Open SEC filing

Monia Brett P

Chief Executive Officer

SaleAlert
Shares
62,970
Price
$82.72
Value
$5,208,979
Open SEC filing

HOUGEN ELIZABETH L

EVP, Finance & CFO

SaleAlert
Shares
6,988
Price
$83.24
Value
$581,702
Open SEC filing

Birchler Brian

EVP, Corp and Development Ops

SaleAlert
Shares
6,179
Price
$83.03
Value
$513,048
Open SEC filing

BENNETT C FRANK

EVP, Chief Scientific Officer

SaleAlert
Shares
5,885
Price
$82.95
Value
$488,141
Open SEC filing

Baroldi Joseph

EVP, Chief Business Officer

SaleAlert
Shares
5,296
Price
$82.96
Value
$439,364
Open SEC filing

Devers Shannon L.

EVP, Chief Human Resources Ofc

Sale 10b5-1
Shares
3,977
Price
$81.34
Value
$323,490
Open SEC filing

Devers Shannon L.

EVP, Chief Human Resources Ofc

Sale 10b5-1
Shares
9,264
Price
$84.62
Value
$783,920
Open SEC filing

Devers Shannon L.

EVP, Chief Human Resources Ofc

Sale 10b5-1
Shares
3,829
Price
$84.62
Value
$324,010
Open SEC filing

Devers Shannon L.

EVP, Chief Human Resources Ofc

Sale 10b5-1
Shares
3,460
Price
$84.62
Value
$292,785
Open SEC filing

Devers Shannon L.

EVP, Chief Human Resources Ofc

Sale 10b5-1
Shares
2,101
Price
$85.36
Value
$179,341
Open SEC filing

Devers Shannon L.

EVP, Chief Human Resources Ofc

Sale 10b5-1
Shares
25,545
Price
$85.36
Value
$2,180,521
Open SEC filing

Swayze Eric

EVP Research

Sale 10b5-1
Shares
18,338
Price
$79.27
Value
$1,453,653
Open SEC filing

Swayze Eric

EVP Research

Sale 10b5-1
Shares
5,125
Price
$78.57
Value
$402,671
Open SEC filing

WENDER JOSEPH H

Director

Sale 10b5-1
Shares
7,429
Price
$81.23
Value
$603,486
Open SEC filing

WENDER JOSEPH H

Director

Sale 10b5-1
Shares
20,571
Price
$80.67
Value
$1,659,362
Open SEC filing

KLEIN JOSEPH III

Director

Sale 10b5-1
Shares
4,000
Price
$80.00
Value
$320,000
Open SEC filing

KLEIN JOSEPH III

Director

Sale 10b5-1
Shares
4,000
Price
$80.00
Value
$320,000
Open SEC filing

KLEIN JOSEPH III

Director

Sale 10b5-1
Shares
4,000
Price
$80.00
Value
$320,000
Open SEC filing

Devers Shannon L.

EVP, Chief Human Resources Ofc

Sale 10b5-1
Shares
16,777
Price
$80.91
Value
$1,357,442
Open SEC filing

HERMAN JOAN E

Director

SaleAlert
Shares
32,000
Price
$72.13
Value
$2,308,240
Open SEC filing

HERMAN JOAN E

Director

SaleAlert
Shares
12,000
Price
$72.13
Value
$865,590
Open SEC filing

Birchler Brian

EVP, Corp and Development Ops

Sale 10b5-1
Shares
8,000
Price
$76.17
Value
$609,379
Open SEC filing

Geary Richard S

EVP, Chief Development Officer

Sale 10b5-1
Shares
18,300
Price
$75.42
Value
$1,380,204
Open SEC filing

Geary Richard S

EVP, Chief Development Officer

Sale 10b5-1
Shares
14,738
Price
$76.10
Value
$1,121,521
Open SEC filing

Geary Richard S

EVP, Chief Development Officer

Sale 10b5-1
Shares
801
Price
$75.01
Value
$60,083
Open SEC filing

Geary Richard S

EVP, Chief Development Officer

Sale 10b5-1
Shares
800
Price
$75.01
Value
$60,008
Open SEC filing

Geary Richard S

EVP, Chief Development Officer

Sale 10b5-1
Shares
905
Price
$75.05
Value
$67,924
Open SEC filing

Geary Richard S

EVP, Chief Development Officer

Sale 10b5-1
Shares
775
Price
$75.05
Value
$58,167
Open SEC filing

“Alert” means a voluntary, unscheduled transaction according to the filing; it is not an investment recommendation. Official source: SEC EDGAR.